Blood Rev. 2006 Nov;20(6):299-318. Epub 2006 May 22
Diagnosis of megaloblastic anaemias
Wickramasinghe SN.
Department of Haematology, Faculty of Medicine, Imperial College, St Mary's Campus, Praed Street, London W2 1PG, UK.
View abstract >
Clin Chem. 2006 Feb;52(2):278-85.
Measurement of total vitamin B12 and holotranscobalamin, singly and in combination, in screening for metabolic vitamin B12 deficiency.
Miller JW, Garrod MG, Rockwood AL, Kushnir MM, Allen LH, Haan MN, Green R.
View abstract >
Semin Vasc Med. 2005 May;5(2):140-55.
Novel and established markers of cobalamin deficiency: complementary or exclusive diagnostic strategies.
Schneede J, Ueland PM.
Department of Clinical Chemistry, Umea University, Umea, Sweden.
View abstract >
Clin Chem Lab Med. 2005;43(7):760-4.
Circadian variation of holo-transcobalamin (holo-TC) and related markers.
Hvas AM, Gravholt CH, Nexo E.
Department of Clinical Biochemistry, SKS, Aarhus University Hospital, Aarhus, Denmark. am.hvas@dadlnet.dk
View abstract >
Clin Chem. 2005 Oct 20; [Epub ahead of print]
Holotranscobalamin and Total Transcobalamin in Human Plasma: Determination, Determinants, and Reference Values in Healthy Adults.
Refsum H, Johnston C, Guttormsen AB, Nexo E.
Department of Pharmacology, University of Oxford, Oxford, United Kingdom, and Institute of Medicine, Section of Pharmacology, University of Bergen, Institute of Basic Medical Sciences, Department of Nutrition, University of Oslo, Oslo, Norway.
View abstract >
Clin Chem Lab Med. 2005;43(10):1058-64.
Evaluation of the technical performance of novel holotranscobalamin (holoTC) assays in a multicenter European demonstration project.
Morkbak AL, Heimdal RM, Emmens K, Molloy A, Hvas AM, Schneede J, Clarke R, Scott JM, Ueland PM, Nexo E.
View abstract >
Curr Drug Metab. 2005 Feb;6(1):47-53.
The usefulness of holotranscobalamin in predicting vitamin B12 status in different clinical settings.
Herrmann W, Obeid R, Schorr H, Geisel J.
Department of Clinical Chemistry, University Hospital of Saarland, 66421 Homburg, Germany. kchwher@uniklinik-saarland.de
View abstract >
J Intern Med. 2005 Mar;257(3):289-98.
Holotranscobalamin--a first choice assay for diagnosing early vitamin B deficiency?
Hvas AM, Nexo E.
Department of Clinical Biochemistry, Aarhus University Hospital, Aarhus C, Denmark. am.hvas@dadlnet.dk
View abstract >
Am J Clin Nutr. 2005 Jun;81(6):1436-41.
Transcobalamin 776C->G polymorphism negatively affects vitamin B-12 metabolism.
von Castel-Dunwoody KM, Kauwell GP, Shelnutt KP, Vaughn JD, Griffin ER, Maneval DR, Theriaque DW, Bailey LB.
Food Science and Human Nutrition Department and the General Clinical Research Center, University of Florida, Gainesville, FL 32611, USA.
View abstract >
Clin Chem. 2004 Jun;50(6):1043-9. Epub 2004 Mar 25.
Holo-transcobalamin concentration and transcobalamin saturation reflect recent vitamin B12 absorption better than does serum vitamin B12.
Bor MV, Nexo E, Hvas AM.
Department of Clinical Biochemistry, AKH, Aarhus University Hospital, Norrebrogade 44, DK-8000 Aarhus C, Denmark. vakurbor@hotmail.com
View abstract >
Br J Diabetes Vasc Dis. 2004; 4 (6): 401-406.
Vitamin B12 Status of Patients Treated With Metformin: A Cross-Sectional Cohort Study
Leif Sparre Hermann; Bo Nilsson; Staffan Wettre
View abstract >
Dement Geriatr Cogn Disord. 2004;17(3):215-21. Epub 2004 Jan 20.
Transcobalamin polymorphism and serum holo-transcobalamin in relation to Alzheimer's disease.
McCaddon A, Blennow K, Hudson P, Hughes A, Barber J, Gray R, Davies G, Williams JH, Duguid J, Lloyd A, Tandy S, Everall M, Cattell H, McCaddon A, Ellis D, Palmer M, Bogdanovic N, Gottfries CG, Zetterberg H, Rymo L, Regland B.
University of Wales College of Medicine, Division of General Practice, Wrexham, UK. andrew@mccaddon.demon.co.uk
View abstract >
Clin Chem Lab Med. 2004;42(6):637-43.
Clinical utility of serum holotranscobalamin as a marker of cobalamin status in elderly patients with neuropsychiatric symptoms.
Nilsson K, Isaksson A, Gustafson L, Hultberg B.
Department of Psychogeriatrics, Division of Clinical Chemistry, University Hospital, Lund, Sweden.
View abstract >
Clin Chem Lab Med. 2003 Nov;41(11):1532-6.
Analysis of the transcobalamin II 776C>G (259P>R) single nucleotide polymorphism by denaturing HPLC in healthy elderly: associations with cobalamin, homocysteine and holo-transcobalamin II.
Wans S, Schuttler K, Jakubiczka S, Muller A, Luley C, Dierkes J.
Institute of Clinical Chemistry, University Hospital Magdeburg, Magdeburg, Germany.
View abstract >
Clin Chem Lab Med. 2003 Nov;41(11):1532-6.
Analysis of the transcobalamin II 776C>G (259P>R) single nucleotide polymorphism by denaturing HPLC in healthy elderly: associations with cobalamin, homocysteine and holo-transcobalamin II.
Wans S, Schuttler K, Jakubiczka S, Muller A, Luley C, Dierkes J.
Institute of Clinical Chemistry, University Hospital Magdeburg, Magdeburg, Germany.
View abstract >
Clin Chem Lab Med. 2003 Nov;41(11):1489-92.
Holotranscobalamin as a predictor of vitamin B12 status.
Hvas AM, Nexo E.
Department of Clinical Biochemistry, Aarhus University Hospital, AKH, Aarhus, Denmark.
View abstract >
Clin Chem Lab Med. 2003 Nov;41(11):1478-88.
Functional vitamin B12 deficiency and determination of holotranscobalamin in populations at risk.
Herrmann W, Obeid R, Schorr H, Geisel J.
View abstract >
Technical Briefs - Clinical Chemistry 49: 2076-2078, 2003
Holotranscobalamin as an Indicator of Dietary Vitamin B12 Deficiency
Zouë Lloyd-Wright1, Anne-Mette Hvas2, Jan Møller3, Tom A.B. Sanders1,a and Ebba Nexø2
1 Nutrition Food & Health Research Centre, King’s College London, Franklin-Wilkins Bldg., 150 Stamford St., Waterloo, London SE1 9NN, United Kingdom;2 Department of Clinical Biochemistry, AKH, Aarhus University Hospital, DK-8000 Aarhus C, Denmark;3 Depa
View abstract >
Amino Acids. 2003;24(1-2):1-12.
Homocysteine in the context of cobalamin metabolism and deficiency states.
Briddon A.
Neurometabolic Unit, Department of Clinical Biochemistry, National Hospital for Neurology and Neurosurgery, London, UK. anthony.briddon@uclh.org
View abstract >
(Clinical Chemistry. 2003;49:1542-1544.) - Technical Briefs
Biological Variation of Holo-Transcobalamin in Elderly Individuals
Andrew McCaddon1,a, Peter Hudson2, Cherie McCracken3, Richard Ellis4 and Anne McCaddon1
1 University of Wales College of Medicine, Division of General Practice, Wrexham LL13 7YP, UK 2 Department of Pathology, Wrexham Maelor Hospital, Wrexham LL13 7TD, UK 3 University Department of Psychiatry, Royal Liverpool University Hospital, Liverpool L6
View abstract >
Kidney Int. 2003 Sep;64(3):1095-1100.
Effect of TCN2 776C>G on vitamin B12 cellular availability in end-stage renal disease patients.
Fodinger M, Veitl M, Skoupy S, Wojcik J, Rohrer C, Hagen W, Puttinger H, Hauser AC, Vychytil A, Sunder-Plassmann G.
Institute of Medical and Chemical Laboratory Diagnostics; and Division of Nephrology and Dialysis, Department of Medicine III, University of Vienna, Austria.
View abstract >
Clinical Chemistry. 2003;49:1195-1198.)
The Transcobalamin (TC) Codon 259 Genetic Polymorphism Influences Holo-TC Concentration in Cerebrospinal Fluid from Patients with Alzheimer Disease
Henrik Zetterberg1,a, Ebba Nexö2, Björn Regland3, Lennart Minthon4, Roberta Boson4, Mona Palmér1, Lars Rymo1 and Kaj Blennow1,
1 Department of Clinical Chemistry and Transfusion Medicine,
View abstract >
Am J Clin Nutr. 2003 Jul;78(1):131-6.
Vitamin B-12 status, particularly holotranscobalamin II and methylmalonic acid concentrations, and hyperhomocysteinemia in vegetarians.
Herrmann W, Schorr H, Obeid R, Geisel J.
Central Laboratory, Department of Clinical Chemistry, Saarland University Hospital, Homburg, Germany. kchwher@uniklinik-saarland.de
View abstract >
J Neurol Neurosurg Psychiatry. 2003 Jul;74(7):959-61.
Low vitamin B-12 status in confirmed Alzheimer's disease as revealed by serum holotranscobalamin.
Refsum H, Smith AD.
Department of Pharmacology, University of Oxford, Oxford, UK.
View abstract >
Clin Chem. 2003 Mar;49(3):455-62.
RIA for serum holo-transcobalamin: method evaluation in the clinical laboratory and reference interval.
Loikas S, Lopponen M, Suominen P, Moller J, Irjala K, Isoaho R, Kivela SL, Koskinen P, Pelliniemi TT.
Department of Clinical Chemistry, Turku University Central Hospital, Finland. saila.loikas@tyks.fi
View abstract >
Clin Chim Acta. 2002 Dec;326(1-2):47-59.
Vegetarian lifestyle and monitoring of vitamin B-12 status.
Herrmann W, Geisel J.
Department of Clinical Chemistry-Central Laboratory, University Hospital of the Saarland, Bld. 40, D-66421 Homburg/Saar, Germany. kchwher@uniklinik-saarland.de
View abstract >
Clinical Chemistry. 2002;48:2064-2065
Cobalamin Status (Holo-Transcobalamin, Methylmalonic Acid) and Folate as Determinants of Homocysteine Concentration
Rima Obeid1, Muhidien Jouma2 and Wolfgang Herrmann1a
1 Department of Clinical Chemistry, University Hospital of Saarland, 66421 Homburg, Germany
View abstract >
Clin Chem. 2002 Oct;48(10):1768-71.
Holo-transcobalamin is an early marker of changes in cobalamin homeostasis. A randomized placebo-controlled study.
Nexo E, Hvas AM, Bleie O, Refsum H, Fedosov SN, Vollset SE, Schneede J, Nordrehaug JE, Ueland PM, Nygard OK.
Department of Clinical Biochemistry, AKH, Aarhus University Hospital, DK 8000 Aarhus C, Denmark. E.Nexo@dadlnet.dk
View abstract >
Clin Lab Med. 2002 Jun;22(2):435-45.
Modern approaches to the investigation of vitamin B12 deficiency.
Ward PC.
Department of Pathology and Laboratory Medicine, University of Minnesota, Duluth School of Medicine, 10 University Drive, Duluth, MN 55812, USA. path@d.umn.edu
View abstract >
Clinical Chemistry. 2002;48:561-562.
Quantification of Holo-Transcobalamin, a Marker of Vitamin B12 Deficiency
Ebba Nexo1a, Anna-Lisa Christensen1, Anne-Mette Hvas1, Torben E. Petersen2 and Sergey N. Fedosov2
1 Department of Clinical Biochemistry, Aarhus University Hospital, DK-8000 Aarhus C, Denmark fax 45-8949-3060, e-mail E.Nexo@dadlnet.dk)
View abstract >
Clin Chem. 2002 Mar;48(3):526-32.
Direct assay for cobalamin bound to transcobalamin (holo-transcobalamin) in serum.
Ulleland M, Eilertsen I, Quadros EV, Rothenberg SP, Fedosov SN, Sundrehagen E, Orning L.
Axis-Shield ASA, Ulvenveien 87, PO Box 206 Okern, N-0510 Oslo, Norway.
View abstract >
Clinical Chemistry. 2002;48:407-409.
Measuring and Interpreting Holo-Transcobalamin (Holo-Transcobalamin II)
Ralph Carmel1a
1 Department of Medicine, New York Methodist Hospital, Brooklyn, NY 11215, and Weill Medical College of Cornell University, New York, NY 10021
View abstract >
Am J Clin Nutr. 2001 Aug;74(2):233-41.
Hyperhomocysteinemia and elevated methylmalonic acid indicate a high prevalence of cobalamin deficiency in Asian Indians.
Refsum H, Yajnik CS, Gadkari M, Schneede J, Vollset SE, Orning L, Guttormsen AB, Joglekar A, Sayyad MG, Ulvik A, Ueland PM.
Department of Pharmacology and the Locus for Homocysteine and Related Vitamins, University of Bergen, Norway. helga.refsum@farm.uib.no
View abstract >
Am J Clin Nutr. 2000 Sep;72(3):762-9.
Signs of impaired cognitive function in adolescents with marginal cobalamin status.
Louwman MW, van Dusseldorp M, van de Vijver FJ, Thomas CM, Schneede J, Ueland PM, Refsum H, van Staveren WA.
Division of Human Nutrition and Epidemiology, Wageningen Agricultural University, Netherlands.
View abstract >
Eur J Clin Invest. 1999 Apr;29(4):321-9.
Holotranscobalamin - a sensitive marker of cobalamin malabsorption.
Lindgren A, Kilander A, Bagge E, Nexo E.
Department of Internal Medicine, Boras Central Hospital, Boras, Sweden.
View abstract >
South Med J. 2002 Sep;95(9):1060-2.
Cobalamin pseudodeficiency due to a transcobalamin I deficiency.
Adcock BB, McKnight JT.
Department of Family Medicine, College of Community Health Sciences, University of Alabama, Tuscaloosa, USA.
View abstract >
J Inherit Metab Dis. 1999 Oct;22(7):765-72.
Transcobalamin II deficiency with methylmalonic aciduria in three sisters.
Bibi H, Gelman-Kohan Z, Baumgartner ER, Rosenblatt DS.
Pediatric Department, Clinical Genetic Institute Barzilai Medical Center, Ashkelon, Israel.
View abstract >
J Am Coll Nutr. 1998 Jun;17(3):235-8.
Cobalamin (vitamin B12) and holotranscobalamin changes in plasma and liver tissue in alcoholics with liver disease.
Baker H, Leevy CB, DeAngelis B, Frank O, Baker ER.
Department of Preventive Medicine and Community Health, University of Medicine and Dentistry, New Jersey Medical School, Newark 07107-3001, USA.
View abstract >
J Clin Pathol. 1996 Sep;49(9):755-8.
Limited value of serum holo-transcobalamin II measurements in the differential diagnosis of macrocytosis.
Wickramasinghe SN, Ratnayaka ID.
Department of Haematology, Imperial College School of Medicine at St Mary's, London.
View abstract >
Crit Rev Clin Lab Sci. 1996;33(4):247-356.
Cobalamin.
Markle HV.
Centenary Health Centre, Scarborough, Ontario, Canada.
View abstract >
Arch Dis Child. 1995 Mar;72(3):237-8
Long-term follow up of patients with transcobalamin II deficiency.
Monagle PT, Tauro GP.
Department of Laboratory Haematology, Royal Children's Hospital, Parkville, Victoria, Australia.
View abstract >
Br J Haematol. 1992 Jan;80(1):117-20.
The neurologic aspects of transcobalamin II deficiency.
Hall CA.
Stratton Veterans Affairs Medical Center, Albany, New York 12208.
View abstract >
Eur J Pediatr. 1991 Oct;150(12):841-3.
Transcobalamin II deficiency: case report and review of the literature.
Kaikov Y, Wadsworth LD, Hall CA, Rogers PC.
Department of Paediatrics, University of British Columbia, British Columbia Children's Hospital, Vancouver, Canada.
View abstract >
Arch Neurol. 1993 Jul;50(7):739-42.
Subacute combined degeneration with high serum vitamin B12 level and abnormal vitamin B12 binding protein. New cause of an old syndrome.
Reynolds EH, Bottiglieri T, Laundy M, Stern J, Payan J, Linnell J, Faludy J.
Department of Neurology, King's College Hospital, Denmark Hill, London, England.
View abstract >
Am J Med Genet. 1990 Feb;35(2):222-8.
Transcobalamin II deficiency presenting with methylmalonic aciduria and homocystinuria and abnormal absorption of cobalamin.
Barshop BA, Wolff J, Nyhan WL, Yu A, Prodanos C, Jones G, Sweetman L, Leslie J, Holm J, Green R, et al.
Department of Pediatrics, University of California San Diego, La Jolla 92093.
View abstract >
Haematologica 2006 Feb;91(2):231-4
The limited value of methylmalonic acid, homocysteine and holotranscobalamin in the diagnosis of early B12 deficiency
Goringe A, Ellis R, McDowell I, Vidal-Alaball J, Jenkins C, Butler C, Worwood M.
Department of Haematology, University Hospital of Wales, Cardiff CF14 4XN, UK.
View abstract >
Haematologica. 2006 Jun;91(6):805-8. Epub 2006 May 16
The effect of recombinant human intrinsic factor on the uptake of vitamin B12 in patients with evident vitamin B12 deficiency.
Hvas AM, Buhl H, Laursen NB, Hesse B, Berglund L, Nexo E
Department of Clinical Biochemistry, Skejby Hospital and Aarhus Hospital, Aarhus University Hospital, Aarhus, Denmark. am.hvas@dadlnet.dk
View abstract >
Age Ageing 2006 Jul; 35 (4):416-22. Epub 2006 May 18
Clinical relevance of low serum vitamin B12 concentrations in older people: the Banbury B12 study.
Hin H, Clarke R, Sherliker P, Atoyebi W, Emmens K, Birks J, Schneede J, Ueland PM, Nexo E, Scott J, Molloy A, Donaghy M, Frost C, Evans JG
Hightown Surgery, Hightown Gardens, Banbury, UK.
View abstract >
Haematologica. 2006 Nov;91(11):1506-12. Epub 2006 Oct 17
Diagnosis and treatment of vitamin B12 deficiency--an update
Hvas AM, Nexo E.
Department of Clinical Biochemistry, Aarhus University Hospital, Skejby, Denmark. am.hvas@dadlnet.dk
View abstract >
Clin Chem. 2005 Nov;51(11):2151-5. Epub 2005 Sep 15
Nonradioactive vitamin B12 absorption test evaluated in controls and in patients with inherited malabsorption of vitamin B12
Bor MV, Cetin M, Aytac S, Altay C, Nexo E.
View abstract >
Haematologica 2006 Feb;91(2):231-4
The limited value of methylmalonic acid, homocysteine and holotranscobalamin in the diagnosis of early B12 deficiency
Goringe A, Ellis R, McDowell I, Vidal-Alaball J, Jenkins C, Butler C, Worwood M.
View abstract >
Eur J Clin Nutr. 2006 Aug 9; [Epub ahead of print]
A longitudinal study of serum cobalamins and its binding proteins in lactating women.
Morkbak AL, Ramlau-Hansen CH, Moller UK, Henriksen TB, Moller J, Nexo E
View abstract >
