As expected Active-B12 (holoTC) levels are low in patients with biochemical signs of vitamin B12 deficiency (1). Low values have been reported in vegetarians (2,3) vegans (4) and populations with a low intake of vitamin B12 (5).

Obeid R, et al Clin Chem 2002;48:2064-5.
Herrmann W et al Clin Chem Lab Med 2003;41: 1478-88.
Herrmann W et al Am J Clin Nutr 2003;78:131-67.

LV/LOV = lactovegetarians and lacto-ovo vegetarians

As expected, extremely low Active-B12 levels are found in untreated pernicious anaemia patients (6)

1. Obeid R et al., Clin Chem 2002 ;48 : 2064-5.

2. Herrmann W et al., Clin Chem Lab Med., 2003 ;41 :1478-88

3. Herrmann W et al., Am J Clin Nutr., 2003;78: 131-36.

4. Lloyd-Wright Z et al., Clin Chem., 2003; 49: 2076-8.

5. Miller JW et al., Clin Chem., 2006 ;52 : 278-85

6. Unpublished results, data on file at Axis-Shield.

News

Coming Soon !  The full video recording of the Euromedlab 2007 Active B12 workshop will be available in the next few weeks, register for your copy.

Live CME Web Conference on vitamin B12 deficiency, Prof. Ralph Green, Dec 13th 2007, register now.

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Meetings

8-11 December, 2007
American Society of Hematology, Atlanta, booth 544
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